Neuro Omega Pro 

Surgical Confidence. Clinical Clarity. Trusted DBS Outcomes. 

 

Overview 

The Neuro Omega Pro builds on Alpha Omega’s legacy of surgical precision, merging microelectrode recording (MER), local field potential (LFP) biomarkers, DBS Lead Evoked Potentials (DLEP), and tablet-based stimulation testing, all in one unified workflow. 

Engineered for neurosurgical and neurology teams, the system bridges the intraoperative and programming stages of DBS patient management to enable better outcomes and greater confidence for treatment. 

  • Microelectrode Recording (MER) — high-fidelity mapping for accurate target localization. 
  • LFP-based Biomarkers in the OR — visualize disease- and symptom-related physiology in real time. 
  • DBS Lead Evoked Potentials (DLEP) — record evoked potentials post-stimulation to confirm placement in the motor STN or GPi in awake or asleep workflows. 
  • Pro Tablet for OR Bedside Testing — perform monopolar reviews on any DBS lead and export OR reports to assist clinical programming. 
  • One HaGuide Software. All DBS Leads. — a new, modern unified interface compatible across manufacturers, supporting monopolar and bipolar recording and stimulation testing. 

 

Four Intraoperative Confirmations 

  1. HaGuide MER – automatic STN target localization with LFP and neuronal activity visualization 
  1. DLEP* – detect stimulation-locked oscillatory responses that localize motor subterritories in STN/GPi. 
  1. LFP Biomarkers – simplify MER interpretation, adjust DBS lead implant depth, and predict symptom relief due to stimulation  
  1. Stimulation Testing (Pro Tablet) – test, visualize, and validate therapeutic contacts. 

* Disclaimer: This page may include information about products that may not be available in your region or country. Please consult the approved indications for use. Content on specific Alpha Omega products is not intended for users in markets that do not have authorization for use.

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DBS Lead Evoked Potentials (DLEP) 

Only on Neuro Omega Pro 

  • Record oscillatory, time-locked responses in STN or GPi motor regions immediately after DBS pulse trains. 
  • Capture DLEP in asleep or awake DBS workflows. 
  • Rank contacts by response magnitude and latency to predict long-term efficacy. 
  • Supported by published evidence demonstrating superior predictive value over spectral (beta) and anatomical-only methods. 

Contact Ranking Predictive Value (Xu et al., 2022):  

  • DLEP – 80.2% 
  • Beta – 49.9% 
  • Anatomy – 66.8% 

DLEP recordings show up to 100% accuracy in localizing motor STN regions, enabling precise placement and better long-term outcomes (Opri et al., 2025).  

 

LFP Hotspots - Seamless Handoff to Neurology 

Elevate Programming with Physiological Insight 

Traditional DBS programming often depends solely on image guidance or monopolar reviews. 
LFP Hotspots from Neuro Omega Pro integrate intraoperative data into neurology workflows, turning complex signals into simple, color-coded maps. 

Key Benefits 

  • Actionable Insights – visualize ring-level and directional biomarkers associated with patient symptoms and disease state. 
  • Complement Existing Methods – combine physiological and anatomical data for confident programming. 
  • Patient-Centered Precision – tailor stimulation to each patient’s unique physiology. 
  • Simplified Interpretation – heat-map visualizations require no advanced training. 

Integrate LFPs into Any Workflow: Supports all major DBS systems (Medtronic, Boston Scientific, Abbott, PINS, and SceneRay). 
 

Add physiological context to familiar programming interfaces for a more complete therapeutic picture. 

 

Pro Tablet — Bedside Testing and Reporting 

  • Monopolar Review on Any DBS Lead – simple, intuitive testing at the bedside. 
  • Clinic-Ready OR Reports – export structured data to guide initial programming and validate adaptive DBS contacts. 
  • Team Alignment – bridges surgery and neurology teams with consistent intra-op to follow-up data. 

 

References:

1. Opri E, Isbaine F, Borgheai SB, Bence E, Deligani RJ, Willie JT, Gross RE, Yong NA,
Miocinovic S. Deep brain stimulation-induced local evoked potentials outperform
spectral features in spatial and clinical STN mapping. medRxiv [Preprint]. 2025 Jun
16:2025.06.14.25329308. doi:10.1101/2025.06.14.25329308. PMID: 40585130;
PMCID: PMC12204254.
2. Xu SS, Lee WL, Perera T, Sinclair NC, Bulluss KJ, McDermott HJ, Thevathasan W. Can
brain signals and anatomy refine contact choice for deep brain stimulation in
Parkinson's disease? J Neurol Neurosurg Psychiatry. 2022 May 19:jnnp-2021-
327708. doi: 10.1136/jnnp-2021-327708. Epub ahead of print. PMID: 35589375.

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Operating System 

Windows 10 64 Bit 

Embedded Computer 

Touch Screen PC 

Input Power 

100-240V, 50-60 Hz 

Main Unit Ports 

Ethernet ports (1 GB)  

1 Remote port (USB)  

2 Audio out (3.5mm stereo) 

Number of Channels 

Total: 122 Channels 

•10 MER channels (5 Micro and 5 Macro) 

• Up to 112 EEG/EcoG/EMG/Sensor channels 

Software Filters 

Micro Channel Contact: 

SPK : 

•High Pass Range: 0 – 600Hz 

•Low Pass Range: 5000 – 9000Hz 

LFP: 

•High Pass Range: 0 – 45Hz 

•Low Pass Range: 200 – 400Hz 

 

Macro Channel Contact: 

LFP: 

•High Pass Range: 2 – 45Hz 

•Low Pass Range: 200 – 400Hz 

Hardware Filters 

Micro Channel Contact: 

•High Pass Range: 0.07 Hz 

•Low Pass Range: 10,000Hz 

 

Macro Channel Contact: 

•High Pass Range: 0.07 Hz 

•Low Pass Range: 10,000Hz 

General Purpose Analog Inputs 

Number of Inputs: 16 Channels 

Input Connector: 

8 BNC and 8 D-type Male connector 

General Purpose Analog Ouputs 

Number of Outputs: 8 Channels 

Output connector: 8 BNC 

General Purpose Single Bit Digital Inputs 

Number of Inputs: 16 Channels 

Input Connectors: 

4 BNC, 12 D-type Female Port 

General Purpose 16-Bit Digital Inputs 

Number of Inputs: 32 Channels 

Input Connectors: 

2x 16 D-type Female Port 

General Purpose Digital Outputs 

Number of Outputs: 16 Channels 

Output Connector: 

8 BNC, 8 D-type Female Port