Dr. Zvi Israel, Director Functional Neurosurgery Hadassah Hospital - HaGuide Navigation Algorithm

Real Time Subthalamic Nucleus Navigation

Alpha Omega, together with Prof. Hagai Bergman and Prof. Zvi Israel and their colleagues, developed the HaGuide algorithm, a real-time software solution designed to accurately detect the Subthalamic Nucleus (STN), demarcating the entrance and exit boundaries using microelectrode recording (MER) during surgery.

In addition, the HaGuide robustly detects subregion boundaries in the STN: the motor Dorsolateral Oscillatory Region (DLOR) and the nonmotor Ventromedial non-oscillatory region (VMNR). Once the HaGuide has identified the STN in all trajectories, it recommends the optimal location for stimulation.

The HaGuide algorithm is integrated into the Neuro Omega and NeuroSmart MER systems. The algorithm is used for targeting the STN, as well as other structures such as the GPi and the VIM during deep brain stimulation (DBS) procedures.

  • Stimulation Recommendation location for optimal therapeutic benefit based on LFP analysis.
  • Displays quantitative changes in background noise and plots dominant LFP frequencies throughout the MER trajectory in real-time.
  • Easy and clear identification of the STN entry and exit
  • Detection of distinct motor and non-motor subregions inside of the STN
  • Visualization of the implanted DBS lead relative to entry and exit of the target
  • Automatic Driving under user control via remote control

" After thirty years of experience with microelectrode recording in different settings, I decided to test HaGuide in some surgeries: HaGuide is the ultimate advising tool for interpreting microelectrode recording".

José Luis Relova, MD, PhD, Santiago Clinic Hospital

"Automatic systems overcome the bias of human operators and enable better STN targeting where electrophysiology interpretation of MER data is not available"

Prof. Hagai Bergman, MD, PhD, Hadassah Medical Center


Disclaimer: This page may include information about products that may not be available in your region or country. Please consult the approved indications for use. Content on specific Alpha Omega products is not intended for users in markets that do not have authorization for use.

Want to hear more about HaGuide Brain Map?

Fill up your details and we will get back to you within 4 business days

Order now
  • Analysis of up to 5 NeuroProbes
  • Compatible with the AlphaProbe directional microelectrode
  • Easy and clear identification of the STN entry and exit, as well as the distinct DLOR-VMNR subregions
  • Displays in real-time Root Mean Square- (RMS) and Power Spectrum Density-(PSD) graphs
  • Visualization of implanted DBS lead relative to identified structures
  • Stimulation Recommendation location
  • Allows MER and stimulation note-taking for dictation or Electronic Medical Records (EMR)
  • Automatic Driving and movement to simulation location under user control via remote control
  • Creates a summary of electrophysiological data and notes that can be viewed on aCare, the cloud based platform for offline viewing from anywhere.